https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13689 Wed 11 Apr 2018 12:02:09 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:11524 Sat 24 Mar 2018 08:10:22 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46 Sat 24 Mar 2018 07:42:14 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22298 Sat 24 Mar 2018 07:17:29 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24697 F0 = 0.017) and 3 months (Pr>F = 0.006), indicating more consistent and predictable improvement in motor outcomes. Conclusion: Early, more-intensive, UL training was associated with greater changes in activation in putative motor (supplementary motor area and cerebellum) and attention (anterior cingulate) regions, providing support for the role of these regions and functions in early recovery poststroke.]]> Sat 24 Mar 2018 07:10:53 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:22755 1.8 and volume >15 ml, core <70 ml). In a second analysis, we compared outcomes of the perfusion computed tomography-selected rtPA-treated patients to an Australian historical cohort of non-contrast computed tomography-selected rtPA-treated patients. Of 635 patients with acute ischaemic stroke eligible for rtPA by standard criteria, thrombolysis was given to 366 patients, with 269 excluded based on visual real-time perfusion computed tomography assessment. After off-line quantitative perfusion computed tomography classification: 253 treated patients and 83 untreated patients had 'target' mismatch, 56 treated and 31 untreated patients had a large ischaemic core, and 57 treated and 155 untreated patients had no target mismatch. In the primary analysis, only in the target mismatch subgroup did rtPA-treated patients have significantly better outcomes (odds ratio for 3-month, modified Rankin Scale 0-2 = 13.8, P < 0.001). With respect to the perfusion computed tomography selected rtPA-treated patients (n = 366) versus the clinical/non-contrast computed tomography selected rtPA-treated patients (n = 396), the perfusion computed tomography selected group had higher adjusted odds of excellent outcome (modified Rankin Scale 0-1 odds ratio 1.59, P = 0.009) and lower mortality (odds ratio 0.56, P = 0.021). Although based on observational data sets, our analyses provide support for the hypothesis that perfusion computed tomography improves the identification of patients likely to respond to thrombolysis, and also those in whom natural history may be difficult to modify with treatment.]]> Mon 11 Mar 2019 12:14:50 AEDT ]]>